Background Cutaneous human papillomaviruses (HPVs) increase the risk of non-melanoma skin cancer in sun-exposed skin. We examined the role of beta-HPV in the development of male external genital lesions (EGLs), a sun-unexposed site. Methods In this nested case-control study (67 men with pathologically-confirmed EGLs and 134 controls), exfoliated cells collected from the surface of lesions and normal genital skin 0, 6, and 12 months preceding EGL development were tested for beta-HPV DNA using a type-specific multiplex genotyping assay. Beta-HPV prevalence was estimated and conditional logistic regression was used to evaluate the association with condyloma, the most common EGL. Results While beta-HPV prevalence among controls remained stable, the prevalence among cases was lowest on the surface of lesion. Detecting beta-HPV on the normal genital skin was not associated with the presence or development of condyloma. Conclusions Cutaneous beta-HPV does not appear to be contributing to pathogenesis in male genital skin.
Pierce Campbell, C. M., Gheit, T., Tommasino, M., Lin, H. Y., Torres, B. N., Messina, J. L., … Giuliano, A. R. (2016). Cutaneous beta human papillomaviruses and the development of male external genital lesions: A case-control study nested within the HIM Study. Virology, 497, 314–322. https://doi.org/10.1016/j.virol.2016.08.002