Cutaneous beta human papillomaviruses and the development of male external genital lesions: A case-control study nested within the HIM Study

3Citations
Citations of this article
17Readers
Mendeley users who have this article in their library.

Abstract

Background Cutaneous human papillomaviruses (HPVs) increase the risk of non-melanoma skin cancer in sun-exposed skin. We examined the role of beta-HPV in the development of male external genital lesions (EGLs), a sun-unexposed site. Methods In this nested case-control study (67 men with pathologically-confirmed EGLs and 134 controls), exfoliated cells collected from the surface of lesions and normal genital skin 0, 6, and 12 months preceding EGL development were tested for beta-HPV DNA using a type-specific multiplex genotyping assay. Beta-HPV prevalence was estimated and conditional logistic regression was used to evaluate the association with condyloma, the most common EGL. Results While beta-HPV prevalence among controls remained stable, the prevalence among cases was lowest on the surface of lesion. Detecting beta-HPV on the normal genital skin was not associated with the presence or development of condyloma. Conclusions Cutaneous beta-HPV does not appear to be contributing to pathogenesis in male genital skin.

Cite

CITATION STYLE

APA

Pierce Campbell, C. M., Gheit, T., Tommasino, M., Lin, H. Y., Torres, B. N., Messina, J. L., … Giuliano, A. R. (2016). Cutaneous beta human papillomaviruses and the development of male external genital lesions: A case-control study nested within the HIM Study. Virology, 497, 314–322. https://doi.org/10.1016/j.virol.2016.08.002

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free