Bioconjugated iron oxide nanocubes: Synthesis, functionalization, and vectorization

25Citations
Citations of this article
58Readers
Mendeley users who have this article in their library.
Get full text

Abstract

A facile bottom-up approach for the synthesis of inorganic/organic bioconjugated nanoprobes based on iron oxide nanocubes as the core with a nanometric silica shell is demonstrated. Surface coating and functionalization protocols developed in this work offered good control over the shell thickness (8-40 nm) and enabled biovectorization of SiO2@Fe3O4 core-shell structures by covalent attachment of folic acid (FA) as a targeting unit for cellular uptake. The successful immobilization of folic acid was investigated both quantitatively (TGA, EA, XPS) and qualitatively (AT-IR, UV-vis, ζ-potential). Additionally, the magnetic behavior of the nanocomposites was monitored after each functionalization step. Cell viability studies confirmed low cytotoxicity of FA@SiO2@Fe3O4 conjugates, which makes them promising nanoprobes for targeted internalization by cells and their imaging.

Cite

CITATION STYLE

APA

Wortmann, L., Ilyas, S., Niznansky, D., Valldor, M., Arroub, K., Berger, N., … Mathur, S. (2014). Bioconjugated iron oxide nanocubes: Synthesis, functionalization, and vectorization. ACS Applied Materials and Interfaces, 6(19), 16631–16642. https://doi.org/10.1021/am503068r

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free