Objective: To document for the first time the successful treatment using human chorionic gonadotropin (hCG) and human menopausal gonadotropins (hMG) of anabolic steroid-induced azoospermia that was persistent despite 1 year of cessation from steroid use. Design: Clinical case report. Setting: Tertiary referral center for infertility. Patient(s): A married couple with primary subfertility secondary to azoospermia and male hypogonadotropic hypogonadism. The husband was a bodybuilder who admitted to have used the anabolic steroids testosterone cypionate, methandrostenolone, oxandrolone, testosterone propionate, oxymetholone, nandrolone decanoate, and methenolone enanthate. Intervention(s): Twice-weekly injections of 10,000 IU of hCG (Profasi; Serono) and daily injections of 75 IU of hMG (Humegon; Organon) for 3 months. Main Outcome Measure(s): Semen analyses, pregnancy. Result(s): Semen analyses returned to normal after 3 months of treatment. The couple conceived spontaneously 7 months later. Conclusion(s): Steroid-induced azoospermia that is persistent after cessation of steroid use can be treated successfully with hCG and hMG. © 2003 by American Society for Reproductive Medicine.
Menon, D. K. (2003). Successful treatment of anabolic steroid-induced azoospermia with human chorionic gonadotropin and human menopausal gonadotropin. Fertility and Sterility, 79(SUPPL. 3), 1659–1661. https://doi.org/10.1016/S0015-0282(03)00365-0