RNA polymerase I is a conserved eukaryotic enzyme that transcribes a single gene to generate precursor ribosomal RNA. Martínez Corrales et al. show that reducing the activity of this polymerase, even only in subsets of adult cells, can promote broad health benefits and longevity in the animal model Drosophila melanogaster.
Martínez Corrales, G., Filer, D., Wenz, K. C., Rogan, A., Phillips, G., Li, M., … Alic, N. (2020). Partial Inhibition of RNA Polymerase I Promotes Animal Health and Longevity. Cell Reports, 30(6), 1661-1669.e4. https://doi.org/10.1016/j.celrep.2020.01.017