Serum Osteopontin Level Correlates with Carotid-Femoral Pulse Wave Velocity in Geriatric Persons

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Osteopontin (OPN) is involved in the regulation of vascular calcification processes. The aim of this study was to evaluate the relationship between fasting serum OPN concentration and carotid-femoral pulse wave velocity (cfPWV) in geriatric persons. Fasting blood samples were obtained from 93 geriatric persons. cfPWV were performed by SphygmoCor system. Serum OPN levels were measured using a commercially available enzyme-linked immunosorbent assay. Geriatric adults who had diabetes (P = 0.0 07) or dyslipidemia (P = 0.0 29) had higher cfPWV levels than those without diabetes or dyslipidemia. The univariable linear regression analysis showed that age (P = 0. 002), waist circumference (P = 0.0 48), body mass index (P = 0.0 04), systolic blood pressure (P = 0.0 01), diastolic blood pressure (P = 0.0 36), pulse pressure (P = 0.0 17), creatinine (P = 0.0 02), and log-OPN level (P = 0.0 01) were positively correlated with cfPWV levels, while the high-density lipoprotein cholesterol (HDL-cholesterol) level (P = 0.0 07) and glomerular filtration rate (P = 0.0 01) were negatively correlated with cfPWV levels among the geriatric adults. Multivariable forward stepwise linear regression analysis of the significant variables also showed that log-OPN (β = 0. 233, R 2 = 0.1 23, regression coefficient: 1.868, P = 0.0 11) was still an independent predictor of cfPWV levels in geriatric persons.




Lee, C. J., Wang, J. H., Chen, Y. C., Chen, M. L., Yang, C. F., & Hsu, B. G. (2014). Serum Osteopontin Level Correlates with Carotid-Femoral Pulse Wave Velocity in Geriatric Persons. BioMed Research International, 2014.

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