Objective: To evaluate if the peri-implantation endometrium shows age variations in lectin patterns, which suggest possible age variations in embryo-maternal recognition. Study design: Peri-implantation endometria of younger (< 30 years of age: n = 13) and older (> 40 years of age: n = 17) normally menstruating women was studied. Endometrial spocimens were routinely fixed in buffered formaline and embedded in paraffin. Sections (5 μm) were studied using seven lectins: DBA (Dolicus biflorus, binding specificity α-D-GalNAc), PNA (Arachis hypogea, binding specificity D-Gal (βl → 3)-D-GalNAc), SBA (Glycine max binding specificity α/β-D-GalNAc > D-Gal), WGA (Triticum vulgare binding specificity (α-D-GlcNAc)(n) and sialic acid), ConA (Canavalia ensiformis binding specificity α-D-Man > α-D-Glc), LTA (Lotus tetragonolobus binding specificity α-L-fucose) and UEA I (Ulex europaeus binding specificity α-L-fucose). Results: No significant differences were found in the glycoconjugates sugar residue content and distribution between the endometria of women < 30 years of age and those of women > 40. Conclusions: Our results suggest that human endometrium does not age, at least while cyclic hormonal stimulation and menstruation are present.
Noci, I., Gheri, G., Gheri Bryk, S., Sgambati, E., Moncini, D., Paglierani, M., … Borri, P. (1996). II. Aging of the human endometrium: Peri-implantation phase endometrium does not show any age-dependent variation in lectin binding. European Journal of Obstetrics and Gynecology and Reproductive Biology, 64(1), 11–21. https://doi.org/10.1016/0301-2115(95)02245-7