Allergy and risk of hematologic malignancies: Associations and mechanisms

Abstract

Increasing evidence indicates that a dysregulated immune system, as the one found in allergic disorders, can affect survival of tumor cells. A possible association between allergies and risk of hematologic malignancies has been examined in several epidemiological studies; however, results were not always consistent.The aim of this review is to report the preclinical and clinical data, which support a correlation between allergy and hematologic neoplasms.Immune system modulation could represent a powerful tool in the prevention and treatment of hematologic malignancies.