Novel lycorine derivatives as anticancer agents: Synthesis and in vitro biological evaluation

25Citations
Citations of this article
16Readers
Mendeley users who have this article in their library.

Abstract

Lycorine, which is the most abundant alkaloid isolated from the Amaryllidaceae family of plants, reportedly exhibits promising anticancer activities. Herein, a series of novel lycorine derivatives were synthesized and evaluated for their in vitro inhibitory activities against seven different cancer cell lines, including A549, HCT116, SK-OV-3, NCI-H460, K562, MCF-7 and HL-60. The results indicated that compounds bearing diverse amine substituents at the C-2 position demonstrated good anticancer activities. The selectivity towards different cancer cell lines of the synthesized derivatives is discussed. © 2014 by the authors; licensee MDPI, Basel, Switzerland.

Cite

CITATION STYLE

APA

Wang, P., Yuan, H. H., Zhang, X., Li, Y. P., Shang, L. Q., & Yin, Z. (2014). Novel lycorine derivatives as anticancer agents: Synthesis and in vitro biological evaluation. Molecules, 19(2), 2469–2480. https://doi.org/10.3390/molecules19022469

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free