Lycorine, which is the most abundant alkaloid isolated from the Amaryllidaceae family of plants, reportedly exhibits promising anticancer activities. Herein, a series of novel lycorine derivatives were synthesized and evaluated for their in vitro inhibitory activities against seven different cancer cell lines, including A549, HCT116, SK-OV-3, NCI-H460, K562, MCF-7 and HL-60. The results indicated that compounds bearing diverse amine substituents at the C-2 position demonstrated good anticancer activities. The selectivity towards different cancer cell lines of the synthesized derivatives is discussed. © 2014 by the authors; licensee MDPI, Basel, Switzerland.
Wang, P., Yuan, H. H., Zhang, X., Li, Y. P., Shang, L. Q., & Yin, Z. (2014). Novel lycorine derivatives as anticancer agents: Synthesis and in vitro biological evaluation. Molecules, 19(2), 2469–2480. https://doi.org/10.3390/molecules19022469