Effect of parkia speciosa hassk peels extract on total cholesterol levels of hypercholesterolemia rats

Abstract

Background: This research aimed to examine the secondary metabolites in the ethanol extract of Parkia speciosa Hassk peels and determine the effect of the P. speciosa Hassk peels on the reduction in total cholesterol levels of male hypercholesterolemia white rats. Methods: Thirty white male rats were divided into six treatment groups (n=5): Group I: normal control (0.5% CMC Na suspension), Group II: negative control (high cholesterol feed), Group III: positive control (suspension simvastatin), Group IV, V, VI: hypercholesterolemia rat received P. speciosa Hassk shell at dose of 300, 400, and 500 mg/kg BW orally for 14 days. The total cholesterol levels were measured on days 0, 14, 28, 35. Results: Quantitative test showed that the ethanol extract of P. speciosa peels contained 0.21% alkaloids (w/w), 8.34% flavonoids (w/w), 4.21% tannins (w/w) and 0.18% saponins (w/w). The ethanol extract of P. speciosa peels at a dose of 300 mg/kg BW was able to reduce total cholesterol levels in hypercholesterolemia white mice (52 mg/dL). Conclusion: The ethanol extract of P. speciosa peels can be considered as an effective treatment for hyperlipidemia disease.