Leptin and adiponectin levels of asthmatic Iraqi children in Hilla Province

Abstract

Objective: To assess the serum leptin and adiponectin in Iraqi children with asthma and compare it with healthy controls in Hilla province. Methods: Leptin and adiponectin were measured in 100 children; 60 newly diagnosed with asthma and 40 non-asthmatic children with a comparable age and sex were enrolled in this study. Asthmatic children subdivided into two groups; 30 patients in each group (obese and non-obese). The age of patients and control ranged between 2 and 12 years. The study was conducted in the Department of Biochemistry, College of Medicine, University of Babylon, leptin and adiponectin were estimated by enzyme-linked immunoassay, enzyme-linked immunosorbent assay technique. Results: An increase in leptin and decrease adiponectin levels in the obese group than in non-obese asthmatic and control groups, with significant difference (p<0.04) and (p<0.03), respectively. Conclusion: Among obese asthmatic Iraqi children, increase and decrease levels of leptin and adiponectin, respectively, indicate the significant association between adipokines and obesity in asthma.