Low-dose clozapine-induced seizure: A case report

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Abstract

Seizures are believed to be a dose-dependent side effect of clozapine. In this case report, we describe a patient who had tonic-clonic seizures after using a low dose clozapine who did not have any seizure risk. The 29-year-old male patient had been followed-up with a diagnosis of schizophrenia for about 5 years. When using clozapine 200 mg/day he had a tonic-clonic seizure with bilateral diffuse epileptic activity in electroencephalography (EEG). In the literature, there are a few case reports about low-dose clozapine-induced seizure. Seizures were observed in our case with a low dose of clozapine (200 mg/day) making this case remarkable. EEG monitoring at regular intervals and examination of plasma levels of clozapine could be useful in preventing the development of seizures.

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Bolu, A., Akarsu, S., Pan, E., Aydemir, E., & Oznur, T. (2017). Low-dose clozapine-induced seizure: A case report. Clinical Psychopharmacology and Neuroscience, 15(2), 190–193. https://doi.org/10.9758/cpn.2017.15.2.190

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