Bruton tyrosine kinase (Btk): Key for signaling via Toll-like receptor 8

Abstract

The contribution of Btk to innate immune responses of myeloid cells is poorly understood. In this issue of Blood, Sochorova and colleagues demonstrate that deficient Btk function selectively impairs dendritic cell cytokine induction in response to viral single-stranded RNAs that activate Toll-like receptor 8 (TLR-8).