The mammalian MyD88 signaling molecule participates in Toll receptor signaling within the cytoplasm. In this issue of Immunity, Marek and Kagan (2012) report that Drosophila (d)MyD88 acts instead at the plasma membrane to sort the signaling adaptor Tube. © 2012 Elsevier Inc..
Goto, A., & Imler, J. L. (2012, April 20). Toll Signaling in Flies and Mammals: Two Sorts of MyD88. Immunity. https://doi.org/10.1016/j.immuni.2012.04.001