Enaminonitriles in heterocyclic synthesis: A route to 1,3-diaryl-4- Aminopyrazole derivatives

Abstract

Benzylcyanide and 4-nitrobenzylcyanide condensed with triethyl orthoformate and piperidine or morpholine to yield 2-Aryl-2-piperidinyl or 2-morpholinylacrylonitriles. These coupled with aromatic diazonium salts to yield the 2-Arylhydrazno-2-Arylethane nitriles in good yields. The latter were converted into 4-Aminopyrazoles in good yields using the Thorpe-Ziegler cyclization. © 2013 by the authors.