Exploring the effects of cigarette smoking on inflammatory bowel disease using mendelian randomization

Abstract

Background. Previous observational evidence has suggested an association between smoking and inflammatory bowel disease (IBD). Methods. We used observational techniques followed by Mendelian randomization to explore whether smoking is a causal factor in the development of IBD and its subtypes. Results. In those who have ever smoked, we observed increased risk of IBD and, in current smokers, we observed increased risk of Crohn disease and decreased risk of ulcerative colitis. However, our Mendelian randomization analyses found little evidence that smoking affects the development of IBD. Conclusion. Overall, our results suggest that smoking does not causally influence the risk of IBD. Lay summary A study investigating the effect of smoking on the risk of developing inflammatory bowel disease using observational and genetic tools. Despite strong observed associations, our overall results suggest smoking does not affect the risk of developing inflammatory bowel disease.