It is known that mammalian rpS3 functions as a DNA repair endonuclease and ribosomal protein S3. It was also observed that several ribosomal proteins or DNA repair enzymes are related to apoptosis. We report here a third function of rpS3, induction of apoptosis. The localization of green fluorescent protein (GFP)-rpS3 is changed to the nuclear membrane when lymphocytic cells undergo rpS3-induced apoptosis. Transient expression of GFP-rpS3 activates caspase-8/caspase-3 and sensitizes cytokine-induced apoptosis. Deletion analysis reveals that the two functions of rpS3, DNA repair and apoptosis, use independent functional domains. © 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Jang, C. Y., Lee, J. Y., & Kim, J. (2004). RpS3, a DNA repair endonuclease and ribosomal protein, is involved in apoptosis. FEBS Letters, 560(1–3), 81–85. https://doi.org/10.1016/S0014-5793(04)00074-2