Generation of a human iPSC line from a patient with a defect of intergenomic communication

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Abstract

Human iPSC line PG64SV.2 was generated from fibroblasts of a patient with a defect of intergenomic communication. This patient harbored a homozygous mutation (c.2243G>C; p.Trp748Ser) in the gene encoding the catalytic subunit of the mitochondrial DNA polymerase gamma gene (POLG). Reprogramming factors Oct3/4, Sox2, Klf4, and cMyc were delivered using a non integrative methodology that involves the use of Sendai virus.

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Zurita, F., Galera, T., González-Páramos, C., Moreno-Izquierdo, A., Schneiderat, P., Fraga, M. F., … Gallardo, M. E. (2016). Generation of a human iPSC line from a patient with a defect of intergenomic communication. Stem Cell Research, 16(1), 120–123. https://doi.org/10.1016/j.scr.2015.12.016

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