Sesquiterpene coumarins from the roots of Ferula sinkiangensis and Ferula teterrima

Abstract

Three new natural sesquiterpene coumarins, isofeterin (1), lehmannolol (3), sinkianone (4), and one known compound, lehmannolone (2), were isolated from the roots of Ferula teterrima and Ferula sinkiangensis. Their chemical structures were established on the basis of spectroscopic analysis, including X-ray crystallography and CD spectrum measurements for determining the absolute configuration of compound 2. © 2006 Pharmaceutical Society of Japan.