To explore the mechanism of acupuncture for delaying aging. Methods: Using the senescence accelerated mouse pattern SAMPIO and the normal aging mice SAMRl as models and applying RT-PCR and digoxin (DIG)-labeled Northern blot technique to observe expressions of NF-E2, YB-1, LRG47 genes in the forebrain, cortex and hippocampus in a 8-month old SANM1 control group, a 8-month old SAMP10 control group, a 8-month old SAMP10 acupuncture group and a 8-month old SAMP10 non-point stimulation group. Results: In the SAMP10 control group, the expressions of NF-E2, YB-1 and LRG47 were down-regulated in the forebrain, cortex and hippocampus, and after acupuncture they were up-regulated and tended to normal. Conclusion: The brain aging of the SAMP10 mice is related with abnormal expressions of NF-132, YB-1 and LRG47 genes; and acupuncture can regulate the expressions of NF-E2, YB-1 and LRG47 genes, strengthening the functions of erythrocyte series, increasing the proliferation of cells and enhancing the cellular immune function in anti-bacteria, hence delaying aging.
Fu, Y., Yu, J. C., Ding, X. R., & Han, J. (2009). Effects of acupuncture on expression of the transcription factors NF-E2, YB-1 LRG47 in the SAMP10 mice. Journal of Traditional Chinese Medicine, 29(1), 54–59. https://doi.org/10.1016/s0254-6272(09)60032-7