The fundamental concept for developing anti-viral modified nucleoside was proposed. An idea to use 4'-C-substituted-2'-deoxynucleoside derivatives based on the fundamental concept was also proposed to solve the problems of the existing highly active antiretroviral therapy (HAART). © 2014 Ohrui H.
Ohrui, H. (2014). A new paradigm for developing antiviral drugs exemplified by the development of supremely high anti-HIV active EFdA. Journal of Antivirals and Antiretrovirals, 6(1), 32–39. https://doi.org/10.4172/jaa.1000092