Novel Mutations in a Patient with ALK -Rearranged Lung Cancer

  • Giri S
  • Patel J
  • Mahadevan D
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Abstract

A variety of mechanisms of crizotinib resistance have been defined in patients with ALK-rearranged lung cancer who no longer have a response to the drug. A case is presented in which the tumor lost the rearrangement and mutations developed in several other genes.

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Giri, S., Patel, J. K., & Mahadevan, D. (2014). Novel Mutations in a Patient with ALK -Rearranged Lung Cancer. New England Journal of Medicine, 371(17), 1655–1656. https://doi.org/10.1056/nejmc1410799

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