Design synthesis and biological evaluation of 3-substituted triazole derivatives

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Abstract

Based on the active site of lanosterol 14α-demethylase of azole antifungal agents, sixteen 1-(1H-1,2,4-triazole-1-yl)- 2-(2,4-difluorophenyl)-3- (N-n-butyl-N-1-substitutedbenzyl-4-methylene-1H-1,2,3-triazole)-2-propanols have been designed, synthesized and evaluated as antifungal agents. Results of preliminary antifungal tests against eight human pathogenic fungi in vitro showed that some of the compounds exhibited excellent activities with broad spectrum. © 2010 Hong Gang Hu.

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Wang, B. G., Yu, S. C., Chai, X. Y., Yan, Y. Z., Hu, H. G., & Wu, Q. Y. (2011). Design synthesis and biological evaluation of 3-substituted triazole derivatives. Chinese Chemical Letters, 22(5), 519–522. https://doi.org/10.1016/j.cclet.2010.11.029

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