Polo-like kinases (PLKs) are marked by C-terminal polo box modules with critical protein interaction and subcellular targeting roles. Slevin et al. in this issue of Structure reveal the architecture of a hidden set of polo boxes from the divergent PLK4, a critical player in centrosome duplication, shedding new light on the evolution of PLKs and their functionally related kinase ZYG-1. © 2012 Elsevier Ltd All rights reserved.
Jana, S. C., Bazan, J. F., & Dias, M. B. (2012, November 7). Polo boxes come out of the crypt: A new view of PLK function and evolution. Structure. Cell Press. https://doi.org/10.1016/j.str.2012.10.008