At the forefront of the Suzuki–Miyaura reaction: Advances in stereoselective cross-couplings

Abstract

The synthesis of optically enriched compounds is a continuing challenge in organic synthesis. While the Suzuki–Miyaura cross-coupling has been used extensively in the construction of sp2–sp2 bonds, only recently has it come to prominence as a useful means to construct stereogenic centres. This chapter describes the latest achievements in the development of stereoselective Suzuki–Miyaura cross-coupling reactions, including advances made both in atroposelective couplings as well as stereoselective C(sp3) couplings. Focus is also given to the mechanistic details of these cross-coupling processes.