Relevance of DNA alkylation damage repair systems in Salmonella enterica virulence

Abstract

Systematic inactivation of pathways involved in DNA alkylation damage repair demonstrated that inactivation of the ada, ogt, tag, uvrA, and mfd genes is required to detect a Salmonella enterica virulence decrease. Furthermore, the fitness of S. enterica, defective in these genes, is lowered only when the bacterium is orally, but not intraperitoneally, inoculated. Copyright © 2010, American Society for Microbiology. All Rights Reserved.