Hepatotoxicity of Schiff bases derived from benzoin salicylaldehyde, aminophenol and 2,4 dinitrophenyl hydrazine

Abstract

Hepatotoxicity of three Schiff bases viz. PDH [N-(1-phenyl-2-hydroxy-2- phenyl ethylidine)-2′,4′ dinitrophenyl hydrazine],PHP[N-(1-phenyl-2- hydroxy-2-phenylethylidine) 2′hydroxy phenyl imine] and HHP [N-(2-hydroxy benzylidine)-2′hydroxy phenyl imine] in both mice with and without Ehrlich Ascites Carcinoma (EAC) was studied. The parameters selected were serum level of the enzymes alanine transaminase, aspartic transaminase, alkaline phosphatase, glucose, blood urea and cholesterol. In mice with no carcinoma there was a modest increase in all the above parameters during the treatment period (10 consecutive days at the dose of 2 mg/kg). After treatment the enhanced values gradually decreased to normal levels. In EAC bearing mice, the toxic effects due to EAC cells in all cases were found to be nullified by treatment of the test compounds. No significant abnormalities in histology of the various organs of the mice were detected due to such treatments.