A novel IgM intranasal intervention against SARS-CoV-2

Abstract

Statement of Signi?cance: IgM and IgA constitute the ?rst line of defense in the respiratory tract against mucosal pathogens. These immunoglobulins assemble into pentamers and dimers respectively. A recent publication in focus highlights the discovery of IgM-14, a novel IgM molecule for prophylactic as well as therapeutic treatment against the emerging SARS-CoV-2 variants.