Detecting "different": Pyrin senses modified GTPases

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Abstract

Pathogenic bacteria secrete effector proteins that target host cell Rho GTPases to manipulate the actin cytoskeleton. A recent study in Nature identifies the Pyrin inflammasome as a sensor of this pathogenic process.

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De Zoete, M. R., & Flavell, R. A. (2014). Detecting “different”: Pyrin senses modified GTPases. Cell Research, 24(11), 1286–1287. https://doi.org/10.1038/cr.2014.101

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