Computer-assisted carotid plaque characterisation

Citations of this article
Mendeley users who have this article in their library.


Objective: To determine the relationship between plaque echogenicity as measured by computer and the incidence of cerebral brain infarction. Patients and methods: Eighty-seven patients with 148 plaques producing more than 50% internal carotid artery stenosis were studied. Sixty-nine plaques were in asymptomatic patients, 35 were associated with amaurosis fugax, 19 with transient ischaemic attacks and 25 with stroke. All patients had a CT brain scan and the presence of ipsilateral cerebral infarction was noted. Images of the plaques obtained with an ATL Ultramark-4 Duplex scanner (7.5 MHz high resolution probe) were transferred to a computer. Using an image analysis program a histogram for each plaque was obtained with the number of pixels plotted against the grey scale (0-225). The median of the grey scale was used as a measure of echogenicity. Results: Fifty-three (36%) of the 148 plaques were associated with ipsilateral CT brain infarction. Plaques with a grey scale median more than 32 (echogenic) were associated with an incidence of 11% (7/64) CT infarction. In contrast, plaques with grey scale median below or equal to 32 (echolucent) were associated with 55% (46/84) incidence of CT infarction (x2 = 30.35, p < 0.001, relative risk = 22, 95% confidence interval from 4.7 to 108). Conclusion: This study indicates that computer analysis of carotid plaque can identify high-risk carotid plaques. The potential of such analysis in the identification of asymptomatic high-risk patients should be explored in further studies. © 1995 W. B. Saunders Company Ltd.




El-Barghouty, N., Geroulakos, G., Nicolaides, A., Androulakis, A., & Bahal, V. (1995). Computer-assisted carotid plaque characterisation. European Journal of Vascular and Endovascular Surgery, 9(4), 389–393.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free