MicroRNA-223 regulates FOXO1 expression and cell proliferation

Citations of this article
Mendeley users who have this article in their library.


In HCT116 colorectal cancer cells, HeLa cervical cancer cells and HuH-7 hepatoma cells, miR-223 is expressed at a low level. Through infection with lentivirus containing miR-223 precursor, miR-233 was overexpressed in all these cells. Interestingly, the expression levels of FOXO1 mRNA and protein, and phosphorylation levels became significantly lower than those of their control. FOXO1 was down-regulated mainly in the cytoplasm, while the nuclear FOXO1 level became relatively high compared to the cytoplasm. As the unphosphorylated active form of FOXO1 increased in the cells, cyclin D1/p21/p27 were up-regulated at either mRNA or protein level. Proliferation of the cells was also greatly inhibited when miR-223 was over-expressed. Therein, our data suggest that miR-223 regulates FOXO1 expression and cell proliferation. © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Author supplied keywords




Wu, L., Li, H., Jia, C. Y., Cheng, W., Yu, M., Peng, M., … Wu, X. Z. (2012). MicroRNA-223 regulates FOXO1 expression and cell proliferation. FEBS Letters, 586(7), 1038–1043. https://doi.org/10.1016/j.febslet.2012.02.050

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free