Determining an optimal cutoff of serum β-human chorionic gonadotropin for assisting the diagnosis of intracranial germinomas

7Citations
Citations of this article
12Readers
Mendeley users who have this article in their library.

Abstract

Background: Beta (β)-human chorionic gonadotropin (β-HCG) is used to confirm the diagnosis and plan treatment of intracranial germinomas. However, the cutoff values of serum β-HCG in diagnosis of intracranial germinomas reported in the literature are inconsistent. To establish an appropriate cutoff value of serum β-HCG for diagnosis of intracranial germinomas, we retrospectively reviewed the records of intracranial tumor patients who received serum β-HCG and α-fetoprotein (AFP) tests for diagnostic purposes at our hospital from 2005 to 2014. Methods: A total of 93 intracranial germinomas and 289 intracranial non-germ cell tumors were included in this study. Receiver operating characteristic (ROC) analysis was used to evaluate the sensitivity and specificity of 3 cutoffs (0.1, 0.4, and 0.5 mIU/mL) for diagnosing intracranial germinomas. The serum β-HCG level of intracranial germinoma patients was further analyzed to investigate the effect of metastasis status and tumor location on serum β-HCG level. Results: The area under the ROC curve was 0.81 (P <.001), suggesting β-HCG is an effective marker. Of the 3 cutoff values, 0.1 mIU/mL possessed a highest sensitivity (66.67%) and good specificity (91%). Although there was no β-HCG level difference between metastatic and non-metastatic intracranial germinoma patients, the diagnostic rate of metastatic neurohypophyseal germinomas was significantly higher than that of its non-metastatic counterpart (P <.05), implying that the location of the germinoma might need to be considered when β-HCG is used as a marker to predict metastasis. Conclusions: Determining an optimal cutoff of serum β-HCG is helpful for assisting the diagnosis of intra-cranial germinoma.

Cite

CITATION STYLE

APA

Zhang, H., Zhang, P., Fan, J., Qiu, B., Pan, J., Zhang, X., … Qi, S. (2016). Determining an optimal cutoff of serum β-human chorionic gonadotropin for assisting the diagnosis of intracranial germinomas. PLoS ONE, 11(1). https://doi.org/10.1371/journal.pone.0147023

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free