Ampicillin pharmacokinetics in azotemic and healthy dogs

Abstract

Background: Little is known about effects of factors such as kidney disease, affecting ampicillin pharmacokinetics in dogs. Objectives: Determine the pharmacokinetics of ampicillin after a single intravenous dose in healthy and azotemic dogs. Animals: Nine dogs presenting with acute kidney injury and 10 healthy dogs. Methods: This was a prospective study. An ampicillin dose of 22.2 mg/kg (mean dose) was administered once intravenously. Blood samples were obtained at timed intervals (just before administration, 1, 2, 4, 12, and 24 hours), analyzed using high-pressure liquid chromatography followed by pharmacokinetic analysis of the plasma drug concentrations. Results: Peak ampicillin concentration (mcg/mL; 97.07 (36.1) vs 21.3 (50.26)), P