Biosynthesis of thiomarinol A and related metabolites of Pseudoalteromonas sp. SANK 73390

22Citations
Citations of this article
44Readers
Mendeley users who have this article in their library.

Abstract

The biosynthesis of the mixed PKS-FAS-NRPS hybrid antibiotic thiomarinol A was investigated using feeding studies to both wild type and mutant strains of the marine bacterium Pseudoalteromonas. Particularly interesting features of the pathway include assembly of the 8-hydroxyoctanoic acid side-chain via chain extension of a C4-precursor (4-hydroxybutyrate), and construction of the pyrrothine unit from cysteine via (HolA-D, F-H) prior to intact incorporation into thiomarinol (catalysed by TmlU). A series of thiomarinol-related and other minor metabolites have been isolated from wild-type and mutant strains. The results of these investigations are rationalised in terms of the overall biosynthetic pathway. © 2013 The Royal Society of Chemistry.

Cite

CITATION STYLE

APA

Murphy, A. C., Gao, S. S., Han, L. C., Carobene, S., Fukuda, D., Song, Z., … Simpson, T. J. (2014). Biosynthesis of thiomarinol A and related metabolites of Pseudoalteromonas sp. SANK 73390. Chemical Science, 5(1), 397–402. https://doi.org/10.1039/c3sc52281d

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free