KARAKTERISTIK KLINIS DAN DERAJAT BERAT GEJALA MOTORIK PENYAKIT PARKINSON DI RSUP SANGLAH DAN RSUD WANGAYA DENPASAR

Abstract

Background: Parkinson's Disease (PD) is the second most common neurodegenerative disorder. The Global Burden Disease (GBD) report published in 2018 estimated there were 6.1 million individuals suffering from PD globally and causing 3.2 million Disability-Adjusted Life Years (DALY) and 211,296 deaths in 2016. Disability mainly caused by motor symptoms. This study aims to determine the clinical characteristics and motor severity in PD patients in Sanglah and Wangaya General Hospital Denpasar. Method: Descriptive observational study with cross-sectional design. Samples taken consecutively from all patients diagnosed with PD at Neurology Polyclinic in Sanglah and Wangaya General Hospital from December 2018 - February 2019. Result: From 47 subjects with PD, 72.3% were male, 83% had onset within 1-5 years, and the mean age was 63.87 ± 8.67 years. As many as 44.7% subjects had Hoehn-Yahr 2 stadium, with an average MDS-UPDRS III score of 35.11 ± 21.39, and 48.9% subjects had mild severity. As many as 59.6% subjects had the status of ON. Motor severity showed a trend that increases with increasing staging, but was not seen when compared to the onset. This result might be affected by the ON/OFF status during examination. Conclusion: Parkinson's disease in Sanglah and Wangaya General Hospital is more common in men and over the age of 50 years, and most are found in moderate severity. There is a trend of worsening motor severity with the increasing Hoehn-Yahr stadium. Examination using UPDRS-III is recommended to be done both on ON and OFF state to get more sensitive results