Danger signals, inflammasomes, and the intricate intracellular lives of chlamydiae

Citations of this article
Mendeley users who have this article in their library.


Chlamydiae are obligate intracellular bacterial pathogens, and as such are sensitive to alterations in the cellular physiology of their hosts. Chlamydial infections often cause pathologic consequences due to prolonged localized inflammation. Considerable advances have been made in the last few years regarding our understanding of how two key inflammation-associated signaling pathways influence the biology of Chlamydia infections: inflammation regulating purinergic signaling pathways significantly impact intracellular chlamydial development, and inflammasome activation modulates both chlamydial growth and infection mediated pro-inflammatory cytokine production. We review here elements of both pathways, presenting the latest developments contributing to our understanding of how chlamydial infections are influenced by inflammasomes and purinergic signaling.




Pettengill, M. A., Abdul-Sater, A., Coutinho-Silva, R., & Ojcius, D. M. (2016, October 1). Danger signals, inflammasomes, and the intricate intracellular lives of chlamydiae. Biomedical Journal. Elsevier B.V. https://doi.org/10.1016/j.bj.2016.07.001

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free