Portable system of programmable syringe pump with potentiometer for determination of promethazine in pharmaceutical applications

8Citations
Citations of this article
20Readers
Mendeley users who have this article in their library.

Abstract

A simple and fast-automated method was developed and validated for the assay of promethazine hydrochloride in pharmaceutical formulations, based on the oxidation of promethazine by cerium in an acidic medium. A portable system, consisting of a programmable syringe pump connected to a potentiometer, was constructed. The developed change in potential during promethazine oxidation was monitored. The related optimum working conditions, such as supporting electrolyte concentration, cerium(IV) concentration and flow rate were optimized. The proposed method was successfully applied to pharmaceutical samples as well as synthetic ones. The obtained results were realized by the official British pharmacopoeia (BP) method and comparable results were obtained. The obtained . t-value indicates no significant differences between the results of the proposed and BP methods, with the advantages of the proposed method being simple, sensitive and cost effective. © 2011.

Cite

CITATION STYLE

APA

Saleh, T. A., Abulkibash, A. M., & Ibrahim, A. E. (2012). Portable system of programmable syringe pump with potentiometer for determination of promethazine in pharmaceutical applications. Saudi Pharmaceutical Journal, 20(2), 155–160. https://doi.org/10.1016/j.jsps.2011.08.005

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free