Asociación entre el polimorfismo rs9939609 del gen FTO y marcadores de adiposidad en población adulta chilena

  • Petermann F
  • Villagrán M
  • Troncoso C
  • et al.
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Abstract

aLex garrido-Méndez 6,d,g , FeLipe pobLete-vaLderraMa 7,d,f , carLos saLas-bravo 8,d,f , robinson raMírez-véLez 9,e,g , nataLia ULLoa 10,b,f,g , Francisco pérez-bravo 11,b,g , carLos ceLis-MoraLes 1,12,d,g (en representación de todos los integrantes del grupo eLHoc, epidemiology of Lifestyle and Health outcomes in chile) Association between FTO (ns9939609) genotype and adiposity markers in Chilean adults Background: Numerous studies have identified the role of Fat-mass-associated-gene (FTO) in the development of obesity. Aim: To investigate the association of FTO gene with adiposity markers in Chilean adults. Material and Methods: 409 participants were included in this cross-sectional study. The association between FTO (rs9939609) genotype and adiposity markers was determined using linear regression analyses. Adiposity markers included were: body weight, body mass index, fat mass, waist circumference, hip circumference and waist/hip ratio. Results: A fully adjusted model showed a significant association between FTO genotype and body weight (2.16 kg per each extra copy of the risk allele [95% confidence intervals (CI): 0.45 to 3.87], p = 0.014), body mass index (0.61 kg.m-2 [95% CI: 0.12 to 1.20], p = 0.050) and fat mass (1.14% [95% CI: 0.39 to 1.89], p = 0.010). The greater magnitude of association was found between the FTO gene and fat mass when the outcomes were standardized to z-score. Conclusions: This study confirms an association between the FTO gene and adiposity markers in Chilean adults, which is independent of major confounding factors. (Rev Med Chile 2018; 146: 717-726)

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Petermann, F., Villagrán, M., Troncoso, C., Mardones, L., Leiva, A. M., Martínez, M. A., … Celis-Morales, C. (2018). Asociación entre el polimorfismo rs9939609 del gen FTO y marcadores de adiposidad en población adulta chilena. Revista Médica de Chile, 146(6), 717–726. https://doi.org/10.4067/s0034-98872018000600717

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