Nephroprotective Effect of Asgand Powder (Withania somnifera Dunal) on Cisplatin Induced Renal Injury in Rats

Abstract

Background: The nephroprotective effect of crude powder of Asgand (Withania samnifera Dunal) was studied against cisplatin induced renal toxicity in wistar albino rats of either sex. Results: The powder of Withania somnifera Dunal at dose level 700 and 1400 mg/kg body wt/day showed reduction in elevated blood urea, serum creatinine and uric acid. It was found to protect kidney damage by cisplatin induced nephrotoxicity as evidenced by oral administration of Asgand (Withania samnifera Dunal) (700 mg/kg) inhibited the rise in blood urea nitrogen (121.7%), Serum cratinine (76.64%), and uric acid (92.7%). There were 92.71% inhibition in the rise of BUN, 92% inhibition in the rise of serum creatinine and 106.6% inhibition in the rise of uric acid with 1400 mg. Conclusion: The findings suggest that the famous Unani herb Asgand Powder possesses marked nephroprotective activity and could offer a promising role in the treatment of acute renal injury caused by nephrotoxins like cisplatin. Keywords: Withania somnifera Dunal, Cisplatin, Asgand, Nephroprotection, Unani Medicine