0347 : Diuretic, antihypertensive and antioxidant effect of olea europaea leaves extract, in rats

  • Ghibu S
  • Morgovan C
  • Vostinaru O
  • et al.
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Introduction: Although, there are known the beneficial effects of the fruits and the olive oil, lately a special attention was given to extracts obtained from olive leaves. The studies have reported that oleuropein (the main active component of olive leaves) has antioxidant, vasodilator, anti-inflammatory properties. Methods: 30 male Sprague-Dawley rats were randomized in 3 groups (n=10) that received orally for seven days: 1. distillate water (control group), 2. Furosemide (10mg/kg), and 3. Leaves extract of Olea europaea (OE). After the first and last dose of vegetal extract, the diuresis and saluresis (urinary Na+ and K<sup>+</sup> concentration) were determined. At the end of the study the systolic blood pressure was recorded, by a non-invasive method. Human erythrocytes were subjected to an oxidative stress induced by 2,2'-azobis (2-amidinopropane) hydrochloride (AAPH) in the presence or absence of increasing concentrations of OE, lipoic acid and trolox (the last two substances were used like reference antioxidants). Results: Furosemide and OE leaves extract induced a significant (p<0.05) increase in rats diuresis and saluresis as compared to control group. For OE extract, the same effect intensity was recorded after the first and the last doses. Also after seven days of treatment, the rats' systolic blood pressure was significantly reduced in OE group. In vitro conditions, in the presence of OE extract, extracellular potassium efflux, the signs of erythrocyte membranes early degradation by oxidative stress, was decreased significantly and dosedependent manner. Conclusions: In our experimental conditions it appears that, OE leaves extract presented diuretic and antihypertensive effects. Also erythrocyte membranes are very significantly protected by the antioxidant compound from OE. Our results could open new perspectives for the use of Olea europaea leaves extract like adjuvant therapy in diseases associated with hypertension and oxidative stress.




Ghibu, S., Morgovan, C., Vostinaru, O., Olah, N., Mogosan, C., & Muresan, A. (2015). 0347 : Diuretic, antihypertensive and antioxidant effect of olea europaea leaves extract, in rats. Archives of Cardiovascular Diseases Supplements, 7(2), 184. https://doi.org/10.1016/s1878-6480(15)30145-2

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