In this issue of Neuron, Napoli et al. (2012) demonstrate that elevated ERK/MAPK signaling in Schwann cells is a crucial trigger for Schwann cell dedifferentiation in vivo. Moreover, the authors show that dedifferentiated Schwann cells have the potential to coordinate much of the peripheral nerve response to injury. © 2012 Elsevier Inc.
Newbern, J. M., & Snider, W. D. (2012, February 23). Bers-ERK Schwann Cells Coordinate Nerve Regeneration. Neuron. https://doi.org/10.1016/j.neuron.2012.02.002