First synthesis, rotamerism and herbicidal evaluation of substituted s-triazines with serinolic fragment

Abstract

First example of melamines and precursors, based on commercially C-substituted-2-amino-1,3-propanediols (pharmaceutical chemistry nomenclature as serinols) in reaction with cyanuryl chloride is reported, e.g. starting from 2-amino-2-methyl-1,3-propanediol. The diastereomerism generated by the more or less restricted rotation about the Csp2(s-triazine) -N< (serinol) bond in this series is for the first time discussed along with a preliminary herbicidal evaluation of a representative term.