Differences in postprandial inflammatory responses to a modern v. traditional meat meal: A preliminary study

Abstract

A low-grade inflammatory response (metaflammation) has been found to be associated with certain chronic diseases. Proposed inducers of this have been aspects of the modern lifestyle, including newly introduced foods. Plasma TAG, and the inflammatory cytokines C-reactive protein (CRP), TNF- and IL-6 were compared in a randomised, cross-over trial using ten healthy subjects before and after eating 100g of kangaroo, or a new form of hybridised beef (wagyu) separated by about 1 week. Postprandial levels for 1 and 2h of TAG, IL-6 and TNF- were significantly higher after eating wagyu compared with kangaroo (P=0002 for TAG at 1h, P<0001 at 2h; P<0001 for IL-6 and TNF- at 1 and 2h). CRP was significantly higher 1h postprandially after wagyu (P=0011) and non-significantly higher 2h postprandially (P=0090). We conclude that the metaflammatory reaction to ingestion of a new form of hybridised beef (wagyu) is indicative of a low-grade, systemic, immune reaction when compared with lean game meat (kangaroo). Further studies using isoenergetic intake and isolating fatty acid components of meats are proposed. Copyright © The Authors 2010.