Pharmacological investigation of phoenix dactylifera L. In azithromycin induced toxicity

Abstract

Background and Objective: Phoenix dactylifera L. (Ajwa dates) is a primeval plant possessing special characteristic in therapeutics. The aim of the current study was to investigate the pharmacological effects of aqueous and methanolic extracts of Phoenix dactylifera L. on liver, lipid and renal parameters in azithromycin treated rabbits. Materials and Methods: Experimental animals were divided into 4 groups (n = 4) group I (Normal rabbits), group II Azithromycin (AZT) (30 mg kg-1 for 7 days), group III Azithromycin+Aqueous extract (AZT-Aqu) AZT 30 mg kg-1 for 7 days daily then aqueous extract of Phoenix dactylifera L. (300 mg kg-1 for 7 days), group IV Azithromycin+Methanolic extract (AZT-Met) AZT 30 mg kg-1 for 7 days daily, then methanolic extract of Phoenix dactylifera L. (300 mg kg-1 for 7 days). The data were analyzed as Mean±SEM. Student’s-test was applied for statistical evaluation by using SPSS version 19. Results: The serum enzyme levels of liver (AST, ALT, LDH and ALP), lipid profile, creatinine and uric acid levels were analyzed for determining treatment effects of Phoenix dactylifera L. Liver function tests, lipid profile, creatinine and uric acid showed (p<0.05) significant decrease and improvement when compared with the group II. The histopathological analysis of liver showed less damage in treated animals. Conclusion: The result of current study concludes that Phoenix dactylifera L. significantly reduces the toxicity induced by azithromycin.