Tissue Distribution of Intraperitoneally Administered (l∼≫3)-/3-D-Glucan (SSG),a Highly Branched Antitumor Glucan, in Mice

Abstract

Distribution of metabolically 3H-labeled (1 -≫3)-/3-D-glucan (3H-SSG) obtained from the culture filtrate of Sclerotinia sclerotiorum IFO 9395, in various tissues after intraperitoneal administration into ICR mice (250 /ig/mouse) was examined. 3H-SSG was mainly detected in liver, spleen, and blood, and a negligible amount was excreted into the feces and excrement within 2 d. The significant amount of 3H-SSG remained in liver and spleen after 1 month. On the other hand, SSG was not incorporated effectively in vivo and in vitro by peritoneal exudate macrophages (0.5 /ig/1 × 106 M. © 1992, The Pharmaceutical Society of Japan. All rights reserved.