Evaluation of swelling ability of scaffold combination of chitosan and hydroxypatite

Abstract

Background: Tissue engineering is an important treatment strategy and used in current and future regenerative the-rapies. To achieve the success of tissue engineering, it is necessary to select a scaffold with certain characteristics. The ability to absorb water or swelling in the scaffold material is one of the properties related to architecture and cell activation. Swelling indicates the ability of the scaffold to absorb or retain water from the scaffold. The swelling ability is expected to absorb water from the surrounding tissue and have an impact on the morphology of the scaffold, espe-cially the combination of chitosan and hydroxyapatite on cell growth. Purpose: Knowing the ability of water absorption (swelling) on the scaffold combination of chitosan and hydroxyapatite for the purpose of bone tissue engineering. Method: Literature review with statistical review method that uses inclusion and exclusion criteria with article design used experimental laboratory in vitro and or experimental laboratory in vivo. Results: There are eight articles show-ing increased swelling ability and five articles showing decreased swelling ability. Conclusion: The combination of chitosan and hydroxyapatite biomaterials can increase and decrease the ability of water absorption on the scaffold so that affects the success of tissue engineering.