SAR for amine salts of carboxylic acids to Hydractinia echinata

Abstract

The relationship between the structure and biological activity (toxicity) SAR of the stoichiometric mixtures between anion and cation (or neutral species) proceeded at pH 8.2 from the different amine salts of benzoic, acetic, oxalic, naphthalene carboxylic acids was determined. Their toxicity was determined by using the metamorphosis (transformation) process of the marine invertebrate Hydractinia echinata (Hydrozoa, Cnidaria) from the freely swimming larva to a sessile polyp as a biological test system. The two components of the stoichiometric mixture, the anion and the cation or neutral species react independently, but in a parallel way, the effectiveness of the cation/neutral species being superior. The studied compounds were grouped by their cationic/neutral structure and measured toxicity. All of these series were also characterized by a calculated mean value of the toxicity. The marine organism, Hydractinia echinata was a good and advantageous alternative for the toxicity testing systems with vertebrate.