Electrochemical determination of acetylsalicylic acid in human urine samples based on poly (diallyldimethylammonium chloride) functionalized reduced graphene oxide sheets

Abstract

In this contribution, a poly (diallyldimethylammonium chloride) functionalized reduced graphene oxide (PDDA-RGO) was synthesized via a simple one-pot hydrothermal approach using urea as reducing agent. The synthesized PDDA-RGO was carefully characterized via various techniques including scanning electron microscopy, transmission electron microscopy, X-ray powder diffraction, Raman spectroscopy and Fourier transform infrared spectroscopy. The synthesized PDDA-RGO was then used as an electrode surface modifier for electrochemically determination of acetylsalicylic acid. Cyclic voltammetry and differential pulse voltammetry were used as determination techniques. Various determination parameters were optimized as well. Moreover, the application of the proposed sensor was successfully applied for acetylsalicylic acid determination in human urine samples.