Sherman et al. commented on the precedence of enantiodivergence, listing a number of congeneric natural products with opposite chirality. However, these "congeners" are not derived from enantiodivergent biosyntheses. Instead, they are antipodes arising from separate enantiomeric biosyntheses. A distinct feature of the biosynthesis of the cyclic pyrrole-imidazole dimers is the production of antipodal congeners without the corresponding enantiomers.
Ma, Z., Wang, X., Wang, X., Rodriguez, R. A., Moore, C. E., Gao, S., … Chen, C. (2015, July 10). Response to Comment on “Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence.” Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.aaa9626