Reversibly addressing an allosteric catalyst in situ: Catalytic molecular tweezers

Abstract

Abiotic allosteric regulation: The design, synthesis, and application of novel, reversible allosteric catalytic molecular tweezers that contain a structural metal, addressable in situ, and two functional catalytic metals are reported (see picture). Kinetic and selectivity data reflect a significant decrease in cooperativity upon opening of the "arms" of the catalyst caused by reactions occurring at the hinge.