Low-dose aspirin treatment improves ovarian responsiveness, uterine and ovarian blood flow velocity, implantation, and pregnancy rates in patients undergoing in vitro fertilization: A prospective, randomized, double-blind placebo-controlled assay

177Citations
Citations of this article
33Readers
Mendeley users who have this article in their library.

Abstract

Objective: To determine the effects of low-dose aspirin on ovarian response, uterine and ovarian blood flow velocity, and implantation and pregnancy rates in patients undergoing IVF. Design: Prospective, randomized, double-blind placebo-controlled assay. Setting: Department of Reproductive Medicine, CER Medical Institute, Buenos Aires, Argentina. Patient(s): Two hundred ninety-eight infertile patients (mean [± SD] age, 35.6 ± 4.09 years) undergoing IVF cycles. Intervention(s): In the treatment group, 149 patients underwent controlled ovarian hyperstimulation and received a daily dose of 100 mg of aspirin. In the control group, 149 patients underwent controlled ovarian hyperstimulation in association with placebo. Main Outcome Measure(s): Number of follicles, number of oocytes retrieved, serum E2 levels, uterine and ovarian pulsatility index, cancellation rate, number of embryos transferred, and implantation and pregnancy rates. Result(s): There were statistically significant differences between the treatment group and the control group, respectively, in the number of follicles (19.8 ± 7.2 versus 10.2 ± 5.3), number of oocytes retrieved (16.2 ± 6.7 versus 8.6 ± 4.6), serum E2 levels (2,923.8 ± 1,023.4 versus 1,614.3 ± 791.7 pg/mL), uterine pulsatility index (1.22 ± 0.34 versus 1.96 ± 0.58), ovarian pulsatility index (1.18 ± 0.31 versus 1.99 ± 0.56), pregnancy rate (45% versus 28%), and implantation rate (17.8% versus 9.2%). Conclusion(s): Low- dose aspirin treatment significantly improves ovarian responsiveness, uterine and ovarian blood flow velocity, and implantation and pregnancy rates in IVF patients.

Cite

CITATION STYLE

APA

Rubinstein, M., Marazzi, A., & Polak De Fried, E. (1999). Low-dose aspirin treatment improves ovarian responsiveness, uterine and ovarian blood flow velocity, implantation, and pregnancy rates in patients undergoing in vitro fertilization: A prospective, randomized, double-blind placebo-controlled assay. Fertility and Sterility, 71(5), 825–829. https://doi.org/10.1016/S0015-0282(99)00088-6

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free