Objective: To determine the effects of low-dose aspirin on ovarian response, uterine and ovarian blood flow velocity, and implantation and pregnancy rates in patients undergoing IVF. Design: Prospective, randomized, double-blind placebo-controlled assay. Setting: Department of Reproductive Medicine, CER Medical Institute, Buenos Aires, Argentina. Patient(s): Two hundred ninety-eight infertile patients (mean [± SD] age, 35.6 ± 4.09 years) undergoing IVF cycles. Intervention(s): In the treatment group, 149 patients underwent controlled ovarian hyperstimulation and received a daily dose of 100 mg of aspirin. In the control group, 149 patients underwent controlled ovarian hyperstimulation in association with placebo. Main Outcome Measure(s): Number of follicles, number of oocytes retrieved, serum E2 levels, uterine and ovarian pulsatility index, cancellation rate, number of embryos transferred, and implantation and pregnancy rates. Result(s): There were statistically significant differences between the treatment group and the control group, respectively, in the number of follicles (19.8 ± 7.2 versus 10.2 ± 5.3), number of oocytes retrieved (16.2 ± 6.7 versus 8.6 ± 4.6), serum E2 levels (2,923.8 ± 1,023.4 versus 1,614.3 ± 791.7 pg/mL), uterine pulsatility index (1.22 ± 0.34 versus 1.96 ± 0.58), ovarian pulsatility index (1.18 ± 0.31 versus 1.99 ± 0.56), pregnancy rate (45% versus 28%), and implantation rate (17.8% versus 9.2%). Conclusion(s): Low- dose aspirin treatment significantly improves ovarian responsiveness, uterine and ovarian blood flow velocity, and implantation and pregnancy rates in IVF patients.
Rubinstein, M., Marazzi, A., & Polak De Fried, E. (1999). Low-dose aspirin treatment improves ovarian responsiveness, uterine and ovarian blood flow velocity, implantation, and pregnancy rates in patients undergoing in vitro fertilization: A prospective, randomized, double-blind placebo-controlled assay. Fertility and Sterility, 71(5), 825–829. https://doi.org/10.1016/S0015-0282(99)00088-6